We have a strict editorial process. dietitians, physicians, and pharmacists. A small boost in cognition in menopausal women given the supplement; needs to be replicated and uncertain if it applies to otherwise healthy youth. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Increased triglyceride levels may occur.Manonai 2008, Because of the estrogen-like effect of P. mirifica, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Buy Kudzu (Pueraria Lobata) Tincture, Organic Dried Roots Liquid Extract 2 oz on Amazon.com FREE SHIPPING on qualified orders Join over 250,000 people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy. The team includes nutrition researchers, registered the roots and flowers of kudzu, Radix and Flos puerariae, respectively, have been used to treat alcohol abuse safely and effectively in China for more than a millennium. Pueraria Lobata Root Extract Applications: 1. If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.com. This is only a brief summary of general information about this product. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. You should talk with your health care provider for complete information about the risks and benefits of using this product. There was no change in blood cells or liver and renal function.Hosoyama 2007, Muangman 2001. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Phytomedicine. Serum FSH, LH, estradiol, progesterone, and immunoreactive-irinhibin were lower in a dose-dependent manner during treatment. The estrogenic activity of kudzu and the cardioprotective effects of its constituent puerarin are also under investigation, but clinical trials are limited. Examine.com does not assume liability for any actions undertaken after visiting these pages, and does not assume liability if one misuses supplements. Botanical Name: Pueraria lobata. Theoretically, drug interactions may occur with the following: May increase pharmacologic and toxicologic effects. Pueraria Mirifica (same genera, different herb), Japanese Knotweed (also called Kudzu), Angelica dahurica (enhances absorption of Puerarin from Pueraria Lobata), Savlia Miltiorrhiza (Danshen) for anti-inflammatory purposes. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect. Pueraria lobata. We comply with the HONcode standard for trustworthy health information -. Each member of our research team is required to have no conflicts of interest, including with supplement manufacturers, food companies, and industry funders. Scientific research does not always agree. It increased luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in both sexes.Malaivijitnond 2004 The mechanism of action involved direct stimulation of the accessory sex organs and suppression of the hypothalamic-pituitary-gonadal axis. We initiated the project by searching the possible target of the Pueraria lobata root extract (P. lobata).We conducted the IC 50 assays of P. lobata on the four diabetes-related proteins: PTP1B, TCPTP, SHP-2 and DPP-4. Pueraria Lobata (Kudzu) is a root plant that appears to have traditional usage in alleviating migraines and hangovers. A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. A small (n= 52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Because of pueraria's estrogen-like effect, use with caution in patients with asthma, diabetes mellitus, epilepsy, migraine, or systemic lupus erythematosus. Safety evaluation of root extract of Pueraria lobata and Scutellaria baicalensis in rats. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. The plant's palmate-type leaves are simple or ovate and contain 3 leaflets in 1 petiole. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. Last updated on Jul 27, 2020. Commercial products are available as topical creams, gels, and soaps, or in oral capsule and tablet dosage forms.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Some clinical studies used 200 to 400 mg extract from root or tuber orally per day. Kudzu Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Tincture Features and description: NON GMO! The mechanism underlying anti-obesity effect of RP was investigated in high-fat diet (HFD) induced obese mice and skeletal muscle cells (C2C12). Becoming a member also unlocks our study database of 400+ supplements and their effects on 600+ health outcomes. Become an Examine Personalized member to access the latest nutrition research on over 400 supplements across more than 600 different health goals, outcomes, conditions, and more. Pueraria lobata 1:2 Fluid extract Common Names: Kudzu, Japanese Arrowroot, Gegen Botanical family: Fabaceae Part Used: Root, flower Dosage: 25-70 ml per week Primary Active Constituents: Isoflavones including puerarin, daidzin, daidzein, genistin, genistein, tectorigenin, glycitin, for this page. For topical products, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. 32 unique references to scientific papers. Medically reviewed by Drugs.com. December 2020; BMC Complementary Medicine and Therapies 20(1) DOI: 10.1186/s12906-020-02998-1. P. mirifica may greatly alter the length of menstrual cycles and suppress ovulation by reducing serum levels of gonadotropins. J Ethnopharmacol. The length of the menstrual cycle increased in monkeys treated with P. mirifica 10 and 100 mg/day of root extract and disappeared completely in monkeys treated with root extract 1,000 mg/day. each outcome. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation. It is applied in pharmaceutical field, pueraria isoflavones is widely used in biopharmaceuticals and API of cardiovascular system agents in China. J Ethnopharma col 1-4-2005;96(1-2):133-138. Kudzu (Pueraria lobata) is one of the earliest medicinal plants used in traditional Chinese medicine. The Human Effect Matrix summarizes human studies to tell you what effects Other name:kudzu root extract,Kudzuvine Root extract,pueraria lobata extract Plant Origin: Pueraria lobataï¼Willd.ï¼Ohwi . Examine.com and its Editors do not ensure that unforeseen side effects will not occur even at the proper dosages, and thereby does not assume liability for any side effects from supplements or practices hosted under the domain of Examine.com. View abstract. This information relates to an herbal, vitamin, mineral or other dietary supplement. to see the full set of research information and references for Pueraria lobata. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Pueraria mirifica is a plant native to Thailand and Burma. 11 Cosmetics Ingredients containing PUERARIA LOBATA ROOT EXTRACT. Our evidence-based analysis on pueraria lobata features The pueraria lobata plant has been used in medical treatments for hundreds of years, and the root, flower, and leaf can all be utilized. extract of pueraria lobata, pueraria lobata (kudzu) root extrac, pueraria lobata (kudzu) root extract, pueraria lobata extract, and pueraria lobata root extract Cancer Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Toxicol Appl Pharmacol 2005;209:263-8. All factual claims are followed by specifically-applicable references. followed by specifically-applicable references. Puerarin acts through brain serotonergic mechanisms to induce thermal effects. Ann Dermatol. 12. Commercial products are available in topical (creams, gels, and soaps) or oral (capsules or tablets) dosage forms. Radix Pueraria lobata (RP) has been reported to prevent obesity and improve glucose metabolism; however, the mechanism responsible for these effects has not been elucidated. The tuberous root varies in size depending on soil condition, but may weigh as much as 100 kg. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Each member of our research team is required to have no conflicts of interest, including with supplement Rating: Best; Categories: Antioxidants, Plant Extracts; See kudzu root Back to Ingredient Dictionary. At Examine.com, our incentives line up with yours — getting unbiased information. Directions: Adults take 1 capsule daily with food or as directed by your doctor and/or qualified health professional. View abstract. It is unsure if this is near the optimal dosage or not. 2012;20(1):17-23. Gluten Free! 1-4-2005;96(1-2):133-138. The team includes nutrition researchers, registered dietitians, physicians, and pharmacists. May Support Vaginal Health. May decrease serum free thyroxine concentrations. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. J Pharmacol Sci 2004;96:420-7. High Quality Kudzu liquid extract - we use classic conventional methods of â¦ Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Thin-layer chromatography analysis has documented varying amounts of phytoestrogens collected from P. mirifica in different locations in Thailand.Malaivijitnond 2006, Cherdshewasart 2007 One of the challenges of large-scale manufacturing of P. mirifica for drugs and cosmetics is resolving these variations in lots. It is applied in food field, pueraria isoflavones can lower blood pressure 2. This information is not specific medical advice and does not replace information you receive from your health care provider. manufacturers, food companies, and industry funders. Jo SJ, Shin H, Paik SH, et al. Commercial manufacturers suggest 250 mg (root or tuber) by mouth every morning and evening. 15588661 This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Select one or more newsletters to continue. Background: the â¦ Menopausal symptoms; general female reproductive health; support of bone, hair, and fingernails; sexual longevity including vaginal lubrication; and enhanced breast size. Life-threatening interaction between the root extract of Pueraria lobata and methotrexate in rats. 13. At higher doses, it increased bone density without affecting accessory sex organs.Urasopon 2007 In a similar study, P. mirifica completely inhibited bone loss in long bones and axial bones in estrogen-deficient female rats.Urasopon 2008 However, the highest dose of P. mirifica root powder (1,000 mg/kg body weight per day) caused an undesired adverse reaction of increased uterine weight. Use with caution in patients with abnormal triglycerides or hypercalcemia. A Puerariae radix extract has been shown to mitigate liver injury and lipid accumulation induced by chronic alcohol intake, 108 that has been attributed to three major isoflavonoids present in this plant â puerarin, daidzin, and daidzein. The researchers suggest 1 mg of P. mirifica is equivalent to 0.52 to 0.75 mcg of ethinyl estradiol.Virojchaiwong 2011. Pueraria lobata â Kudzu New! It is perhaps better known by its Japanese name: kudzu. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Because of its phytoestrogen-like effects, use pueraria with caution if diagnosed with an estrogen-dependent neoplasia, pulmonary embolism, liver dysfunction or disease, or anemia. Category. She is known worldwide as The Cosmetics Cop and creator of Paulaâs Choice Skincare. mirifica decreased neuronal cell death in a time- and dose-dependent manner against neurotoxic agents in an Alzheimer disease model in vitro.Sucontphunt 2007, Sawatsri 2004 Mechanism of action may be associated with an effect on synaptic density by inducing synaptophysin expression via estrogen receptor.Chindewa 2008, Spinasterol, an active cytotoxic component of P. mirifica, was active against certain gynecological cancer cell lines and activates estrogen receptors ER-alpha and ER-beta. This page features 32 references. Type 2 diabetes mellitus is a fast-growing epidemic affecting people globally. there is, and how strong these effects are. Efficacy and Safety of Pueraria lobata Extract in Gray Hair Prevention: A Randomized, Double-Blind, Placebo-Controlled Study. Examine.com is intended to be used for educational and information purposes only. The report provides an understanding of the global Pueraria Lobata Root Extract industry competitors, â¦ 150+ studies summarized across 25 different categories every month. This item: Kudzu Alcohol-Free Liquid Extract, Organic Kudzu (Pueraria lobata) Dried Root Glycerite Hawaii Pharmâ¦ $24.95 ($12.48 / 1 Fl Oz) In Stock. Commercial manufacturers suggest a dosage of 250 mg of active ingredients from the root orally every morning and evening. Some clinical studies used 200 to 400 mg (extracted from the root or tuber) by mouth per day. This information should not be used to decide whether or not to take this product. We have a strict editorial process. A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. Paula Begoun is the best-selling author of 20 books about skincare and makeup. Pueraria lobata has on your body, how much evidence Habitat: Kudzu is native to India, China, and Japan. A wide variety of pueraria lobata root options are available to you, There are 130 suppliers who sells pueraria lobata root â¦ mirifica had an estrogenic action in aged menopausal monkeys by changing the sexual skin area around the perineum to the base of the tail to a reddish pigmentation.Trisomboon 2006 FSH may be a candidate marker for the study of P. mirifica's estrogenic effects in female monkeys if changes in urinary hormones are used as an indicator.Trisomboon2007, Trisomboon 2007, In a 24-week randomized, double-blind, placebo-controlled trial of 51 postmenopausal women, oral P. mirifica exhibited estrogenicity on vaginal tissue, alleviated vaginal dryness symptoms and dyspareunia, improved signs of vaginal atrophy, and restored atrophic vaginal epithelium.Manonai 2007 In another clinical trial of 51 postmenopausal women 46 to 60 years of age, P. mirifica tuberous root had an estrogen-like effect on bone turnover rate at a dose of 20, 30, and 50 mg/day for a 24-week period.Manonai 2008 Phase 1 to 3 trials in Thailand compared the estrogenic effect of P. mirifica to conjugated equine estrogen in relieving climacteric symptoms in perimenopausal women.Lamlertkittikul 2004, Chandeying 2007, A small (n=52) clinical study evaluated oral P. mirifica at 25 and 50 mg over 6 months in relieving menopausal symptoms, and reported efficacy for both doses. No significant influence on circulating LDL-C has been noted with supplementation. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. All factual claims are mirifica also had an estrogenic effect on a human HepG2 hepatoma cell line that contained an estrogen receptor and a luciferase reporter gene; this evidence indicates that metabolic activation of P. mirifica promotes estrogenic activity.Lee 2002 Another study also documents that estrogenic activity may result from metabolic activation of liver enzymes.Cherdshewasart 2008, The proposed mechanism of action involves strong competitive binding of the plant's phytoestrogens to ER-alpha and/or synthesis suppressor of ER-alpha.Cherdshewasart 2007, Pretreatment of rats with P. mirifica (1,000 mg/kg body weight per day tuberous root powder) resulted in decreased virulence of rat mammary tumor development from 7,12-dimethylbenz(a)anthracene (7,12-DMBA). Kudzu is being investigated for its potential use as a therapy for alcoholism; however, sufficient and consistent clinical trials are lacking. Suvatabhandu.Common Name(s): Kwao Keur, Kwao Krua, Kwao Kruea, White Kwao Krua. Results indicated that P. lobata exhibited high PTP1B inhibitory activity with IC 50 of â¦ Available for Android and iOS devices. turmeric, echinacea, saw palmetto, milk thistle, Ginkgo Biloba. This page is regularly updated, to include the most recently available clinical trial evidence. Search by keywords . Some of the isoflavonoids in P. mirifica had antioxidant activity similar to that of alpha tocopherol or vitamin E.Cherdshewasart 2008P. That's why we don’t sell any advertising or supplements. For breast enlargement, manufacturers suggest a twice-daily topical application to the breast area for 3 to 5 minutes until fully absorbed. The main plant sources of Pueraria extract are the dried roots of Pueraria Lobata Willd Ohwi or Pueraria Thomsonii Bentn, which are commonly known as âPueraria Lobataâ. "Pueraria lobata," Examine.com, published on 30 September 2013, last updated on Other Common Names: Kudzu vine, Japanese arrowroot, ge gen (ge hua) (Chinese), bidari kand (Sanskrit). Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder , Find Complete Details about Iso Manufacturer Supply Natural Pueraria Lobata Extract Powder,Pueraria Lobata Powder,Pueraria Lobata Extract from Herbal Extract Supplier or Manufacturer-Xian Pincredit Bio-Tech Co., Ltd. This page features 32 references. Studies in mice found that P. mirifica does not affect male fertility or the hypothalamus-pituitary-testis axis.Jaroenporn 2006 The testis, epididymis, and seminal vesicle all had normal histopathology in P. mirifica -treated male mice. The plant species is rich in phytoestrogens, and postmenopausal women in Thailand have consumed it for more than 100 years citing its beneficial estrogen effects.Manonai 2008 In traditional Thai medicine, it is common to use P. mirifica as a skin moisturizer, to improve regrowth of hair, to improve body flexibility and sexual performance, and to firm and enlarge the breasts.Malaivijitnond 2006 Commercial products containing pueraria are continually introduced into the world marketSookvanichsilp 2008 and have become popular in Thailand, Korea, and Japan.Malaivijitnond 2006 Most commercial products are available as topical rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes.Sookvanichsilp 2008, Malaivijitnond 2006, Chansakaow 2000, Liang 2000, Roufs 2007, Yagi 2007, Tehara 2006, Liu 2005, Konoike 2006, Ishiwatari 2003 Since 1999, domestic and global demand for the raw materials from P. mirifica roots or tubers has increased, resulting in intense harvesting of the plant from the forests of Thailand.Cherdshewasart 2007, Isoflavones, coumestans, and lignans are the 3 main classes of phytoestrogens. Also use with caution in patients with abnormal triglyceridesManonai 2008 or hypercalcemia.Manonai 2008, Urasopon 2007, Urasopon 2008, High doses of P. mirifica caused general and genotoxicity in animals.Saenphet 2005 Rats treated with aqueous and ethanolic root extracts of P. mirifica had significantly lower body weight gain and lower packed red cell volume; the plant also had mutagenic activity.Sanchanta 2005 A root extract dosage of 100 mg/kg had adverse effects on mating efficiency and reproduction in female mice.Jaroenporn 2007 No estrogen hormone activities were found in egg and chicken meat tissue or rats.Tubcharoen 2003, Tubcharoen 2003 The median lethal dose for oral consumption of P. mirifica root powder in mice was 2,000 mg/kg body weight per day.Cherdshewasart 2003. Arm yourself with the knowledge you need to make the right decisions about your health. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. The direction and size of the supplement's impact on In sex-hormone–deficient male rats, treatment with P. mirifica root powder completely inhibited bone loss in long bones and axial bones. HIGH or The combination was blended overnight in a rotating mixer and pelleted (Test Diet, Richmond, IN). Become an Examine.com member to get access to the latest research. About the Experts. Our independent, unbiased approach reveals what works (and what's a waste of time and money). The benefits of Pueraria are seemingly endless; some people use it to alcoholism, heart and circulatory problems, upper respiratory problems, and skin problems. May affect concentration of these medications. Avoid use if hypersensitive to any of the components of product. Scientific Name(s): Pueraria mirifica Airy Shaw et. It contains around 20 species of herbaceous or woody vines, all native to Asia. No significant influence detected on symptoms of menopause (as assessed by rating scales), No significant influence have been detected on total cholesterol.
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